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KMID : 0616120120430010059
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 1 p.59 ~ p.65
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Effects of Herbal Complex on Atopic Dermatitis in BALB/c Mice
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Lee Geum-Seon
Jung Hyun-Mi
Oh Se-Koon
Cheong Jae-Hoon
Kang Tae-Jin
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Abstract
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Atopic dermatitis (AD) is a common chronic inflammatory disease of preceding the development of allergic disorders. The incidence of AD is increasing and it causes problems with administrative costs. Therefore, no side effects, easyto- use development of AD treatment is needed. The aim of this study was to evaluate whether PBMCAT, a functional extract from herbal complex was effective to treat the AD mice. AD was induced by patching ovoalbumin on the backside in BALB/ c mouse and then mice were topically treated with PBMCAT. Elidel cream® (pimecrolimus, PL) was used as a control. Scratching counts (SC) and clinical skin severity (CSS) were measured, and total serum IgE level was also measured. After inducing AD, SC and CSS were increased. The total serum IgE level was also increased in AD-induced mice. Treatment with PBMCAT significantly decreased SC, CSS, and serum IgE concentration in mice. Especially, treatment of PBMCAT 0.1% in BALB/c mice more effected than PL. These results suggest that the ointment of PBMCAT may enhance the process of AD healing by influencing phase of allergic reacting.
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KEYWORD
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Atopic dermatitis, IgE, Herbal complex, Pimecrolimus
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